Revanesse®

At the core of Prollenium® lies a profound dedication to its customers. Customer feedback drives innovation and guides its every move. Proudly crafted in Canada, the Revanesse® dermal fillers embody Canadian excellence and are manufactured exclusively in two facilities in Ontario. Established in 2002, Prollenium® is a pioneer in the US market and boasts FDA clearance. What distinguishes Prollenium® is its unwavering commitment to improvement. With an in-house Research and Development team, it continuously refines formulations and technologies, making dermal fillers its sole focus and passion. Welcome to a world where beauty meets innovation.

How Revanesse® is made:

Revanesse® blends high molecular weight (HMW) hyaluronic acid (HA) with minimal levels of BDDE. HMW HA closely mimics the body’s natural hyaluronic acid, requiring reduced BDDE for stabilisation and decreasing the likelihood of the immune system recognising the filler particle as a foreign object.

The gel undergoes transformation into spherical particles through a proprietary wet milling process. Spherical particles, known for their reduced surface area, mitigate inflammatory reactions compared to irregularly shaped particles or those with a larger surface area.

Revanesse achieves various rheologies by modifying several properties of its HA gels. Tailoring its approach to each indication, it adjusts the degree of cross-linking and particle size and incorporates linear HA as necessary. This customisation enables Revanesse to develop unique properties tailored to specific applications.

The purification process is meticulously optimised to eliminate residual BDDE and toxins thoroughly. Revanesse achieves a purer product through its distinctive 7-day dialysis procedure while neutralising pH and balancing osmolality. This step ensures the consistent performance Revanesse is renowned for, ensuring that what you see is precisely what you get.

During this interview, Ario Khoshbin, CEO and Founder of Prollenium Medical Technologies, delves into the inception of the company and shares his outlook on its future trajectory.

What sets Revanesse® apart from its top competitors?

Scientific evidence supports the role of smooth and spherical particles in enhancing tissue integration, thereby minimising the likelihood of eliciting a foreign body reaction. These specialised particles, characterised by their uniformity and rounded shape, facilitate seamless integration with surrounding tissues, promoting optimal aesthetic outcomes and long-term patient satisfaction.

When considering dermal fillers or other medical-grade products, it’s essential to prioritise formulations that incorporate these smooth and spherical particles. By doing so, healthcare providers can ensure improved patient safety and satisfaction and a reduced risk of adverse reactions.

At Prollenium, they recognise the significance of utilising advanced technologies and formulations that leverage smooth and spherical particles. Their commitment to excellence drives them to refine their products continually, ensuring they meet the highest quality, safety, and efficacy standards.